Syn Pharma Synozole 1.25 Letrozole (Femara)
Letrozole (trade name Femara) is an oral aromatase inhibitor (AI) used in the treatment of hormonally responsive breast cancer after surgery.
1.25mg / 50 ct
What is Letrozole?
Letrozole is used in the treatment of different kinds of male infertility by indirectly increasing their testosterone levels. It is also popular among bodybuilders for increasing muscle strength and boosting testosterone levels. In bodybuilders, it is also utilized in decreasing gynecomastia which occurs while consuming anabolic steroids for muscle mass accumulation.
Letrozole for Bodybuilding
Letrozole works to prevent estrogen production, which in turn increases testosterone productions. Still, confused? Let us make it simpler for you.
In men, a small quantity of free testosterone is converted into estradiol, which is a version of estrogen. With the increase in age, the body of men starts producing less testosterone, and more estradiol. Higher estrogen levels are linked to infertility.
For muscle builders particularly, estrogen levels need to be regulated as, they’re linked to a gain in weight, decreased growth in muscle, man breasts or gynecomastia, and lowered sex drive.
How to use Letrozole
It’s quite easy to use any medicine, so what’s the point of delineating the usage directions of letrozole? Well, the answer is, there is a set of guidelines specific to every drug which need to be followed to get maximum benefits from that medication. The patient guideline pamphlet contains all the essential information required for a patient using letrozole for the first time. You must consult your physician in case of any questions or emergency.
This drug is consumed orally, once a day along with food or without it. It must be consumed as per the directions of your physician. This drug should be used frequently for getting the best positive results. To avoid the hassle of forgetting about the drug consumption each day, as it so happens we recommend crossing out the prescribed days on your calendar to help with the drug uptake regularly.
Mechanism of Action of Letrozole
Letrozole is a potent drug belonging to the class of drugs called aromatase inhibitors. These drugs are used to decrease the conversion of estrogen, as they inhibit the enzyme aromatase, required in a significant step in estrogen hormone production. Letrozole is a nonsteroidal inhibitor of estrogen production with antitumor activity. This action helps in letrozole fertility.
It reversibly and selectively inhibits aromatase. This drug works by obstructing the activity of aromatase, which is used in the conversion of androgens to estrogens in a process known as aromatization, hence the name aromatase. This drug is orally active and is an antiestrogen. This drug prevents the production of estrogen by attaching competitively to aromatase. This mechanism aids in Letrozole bodybuilding.
Optimal Letrozole Dosage
The favorable dose consumption of this drug depends on the medical condition of a person, and the effects for which that medication is being used. The general optimal dosage of this drug is usually one tablet consumed per day. This drug comes in the form of 2.5mg tablets. You should try to take letrozole around the same time every day so that it can work better, and your body’s natural clock can better grow accustomed to it.
You must swallow the whole tablet with a glass of water. You mustn’t try to crush or chew it.
The generic name of this drug is Letrozole, which is generally sold under the brand name of Femara among others.
Interactions with other Medications
This medication has the possibility of interfering or interfacing with other drugs that you are possibly using for other medical conditions. The drug interactions might alter the efficacy of a drug or multiply the serious side effects risk.
Some medications which might interfere with letrozole are, estrogens, like ethinyl estradiol, or conjugated estrogens, estrogen blockers like anastrozole or tamoxifen, and tibolone. Tamoxifen results in blood letrozole levels decline if consumed together. As Letrozole is an anti-estrogen drug, so the estrogen-containing substances result in nullification of the effects of letrozole.
This medication cannot be consumed alongside tamoxifen or ethinylestradiol, both of which work to reduce the effects or levels of letrozole by acting as antagonists. The performance of letrozole needs to be carefully monitored when given with dengue vaccine, letermovir, cholera vaccine, siponimod, or eluxadoline.
Are there any Side Effects of Letrozole?
Yes of course! This medication is no different than any other drug, so its use is also presented by a possibility of various side effects including,
- Extreme sweating
- Loss of hair
- Aches in muscles, bones, and joints
- Digestive problems
- Problems with sleeping
- Hot flashes
- Extremely high levels of testosterone
You will need to notify your physician if any of these symptoms exacerbate or persist for prolonged periods.
Side effects like severe allergic reaction are rare, however, in case of symptoms like extreme rash, itching, swelling, labored breathing, and drowsiness, you must seek immediate medical attention.
You should visit your doctor right away, in case you notice serious side effects like,
- Fractures in bone
- Mode alterations
- Swelled legs and arms
- Blurriness of vision
- Extreme fatigue
- Yellowing of the skin and eyes
- Dark-colored urine
Are There any Storage Guidelines and Precautions?
Yes! This medication needs to be stored in the holder that it came in, must be closed tightly, and kept out of reach of children. It needs to be stored at room temperature, in a cold dry environment, away from excessive sunlight, warm temperatures, and humidity. So if you’re used to storing your medications in your bathroom cabinet, you’ll need to mend your ways for this medicine.
- Dellapasqua, S., 2010. Letrozole. Expert Opinion on Drug Metabolism and Toxicology, 6(, pp. 251-259.
- Dowsett, M., 1999. Drug and hormone interactions of aromatase inhibitors.. Endocrine-Related Cancer.
- Peivandi, S., 2019. Effect of letrozole on spermogram parameters and hormonal profile in infertile men A clinical trial study. NCBI.
Frequently Asked Questions (FAQs)
How to take letrozole for fertility?
Using 2.5 mg letrozole pill once a week has proved to be extremely significant in the restoration of infertility in men for a period ranging from 2 to 21 months. These results were shared by a research group working at CHUM, San Diego.
How long does letrozole stay in your system?
In the light of conducted research, it was found that approximately 90% of radio-tagged letrozole is excreted in the urine. Letrozole terminal half-life was found to be 2 days, with normal plasma levels following regular 2.5mg dose being restored in 2-6 weeks.
What happens when you stop taking Letrozole?
Many people fear that discontinuing this drug will be immediately accompanied by withdrawal symptoms; however, you don’t need to worry as this drug has not shown to cause any known withdrawal symptoms.
Syn Pharma Frequently Asked Questions
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More About Us
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Yes, we offer bulk mix and match discounts on orders of 5, 15, and 25 units orders. Discount will be automatically taken off at checkout without having to do anything on your end. The structure applies to all regular prices items as follows:
Buy 5 items Get $5 Off Each Item
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We only deal with the very best steroid suppliers in Canada. Whenever they bring something new to us, we test it out first hand and make sure it meets all of our quality checks and human reviews. Only after its been tested will we add it to the site to be offered to customers.
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We do from time to time ask people to test products for us here at Canadian Anabolics. This is reserved for our loyal customers that support us, so if you are a dedicated customer to Canadian Anabolics you do have a great chance to test new products free of charge when they come up.
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All inquiries should be sent via the contact form including the following information. Brand name, link to website, link to reviews, number of products in the line, and how long the line has been in business. Upon review if we are interested we will reply back looking for a price list. If you have the best steroids in Canada we want to hear from you!
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Absolutely not, we only ship steroids within Canada to verified shipping address. If you place an order with an address outside of Canada the order will be cancelled.
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We send tracking everyday after we drop off at Canada Post. Should you not receive your tracking within 2 business days please first check your spam/junk box. If it’s still not in their please reply to your order confirmation email asking for an update. We ship Monday-Friday (Excluding Holidays)
Q: What currency are your prices in?
The prices are in CAD (Canadian dollars)
Q: Is there a minimum order amount?
No minimum order however standard shipping fees apply. $25 for Xpresspost & $45 for Priority.
Q: What payment methods do you accept?
Interac E-Transfer, Bitcoin & Electronic Funds Transfer ( EFT).
Q: Can I use Paypal?
No, at this moment, we are working on a solution however are not ready to implement at this time
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As soon as you place your order, you’ll receive the payment instruction on how to pay via interac e-transfer. It’s important that you carefully read the instructions and do not include any note in the e-transfer such as product names, order number, or anything relating to “steroids”... we all know you are excited about buying the best steroids in Canada however please keep the secret to yourself and not the banks.
Q: Where do you ship to?
Please check out our service areas for all the places that we ship. Note that we only ship within Canada Only
How do you ship?
Canada Post Xpresspost is our standard method of shipment. 3-5 business days across Canada. You can also select Priority shipping which will be 1-3 business days across Canada.
Q: Where do you ship from?
All of our orders are always shipped Canada domestic, so there is never any customs involved or any risk at all to you when ordering through us.
Q: How much do you charge for shipping?
Canada Post Xprsspost is a flat rate $25 for shipping. Priority is $45. If the order is over $350 you qualify for free shipping with Canadian Anabolics.
Q: Do you ship to PO boxes?
Yes. Although we do not recommend this option as we can not guarantee signature upon request.
Q: Do you provide a tracking number?
Yes absolutely, upon shipment you will receive a tracking number to your inbox and you can track your order to your door. Please check your junk box if you do not see it in 1-2 business days. If still nothing, please message us in the message box below.
Q: Why is my tracking number not showing online?
The tracking number can take a while to appear, sometimes it only appears in the system the following day. Please be patient, it will start to work.
Q: What if Canada Post loses my package?
If Canada Post loses your package we will replace it. If Canada Post says “delivered” and the signature is verified we consider it to be delivered. All deliveries are sent with “Signature Required” to be part of our guaranteed delivery program. If you wish to have your package sent with no signature required, you take on all liability for the package.
Q: Is there a risk of seizure?
All mail shipped within Canada does not go through customs therefore domestic mail cannot be seized. By federal law domestic mail can only be opened by the receiver.
Q: By mistake I gave you a wrong mailing address. What happens now?
If you provided us with a wrong or incomplete mailing address we will not be able to retrieve your package. Please double check your mailing address before ordering. We will not be responsible for your mistake.
Q: Is signature required on delivery?
Yes if you’d like to be part of our guaranteed delivery program. Should you request “No Signature” upon delivery, the responsibility falls upon yourself.
Q: What is your Turnaround time?
Orders ship within 1-3 business days after clearing payment. This means you’ll get the best steroids in Canada delivered to your door quickly!
Q: What if none of these are my questions
We have 24 -7 live chat customer service or email us and we will get back to you as soon as possible.
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We can't accept any returns because of our quality control measures that we have in place. Please email us and we will do what we can to help you in your situation.
Q: Can I pick up my order?
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No, we are strictly a mail order steroid marketplace only.
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You can check the status of your order anytime by logging into your account and going to the "Orders" section.
Check your email in box or tracking number on the Canada Post website