Jun
Instead of tamoxifen or raloxifene, aromatase inhibitors (AIs) might be a better choice for post-menopausal women with a higher risk of breast cancer and who are thinking about taking treatment to lessen that risk.
Some drugs exist to help ladies reduce their risk of breast cancer. However, Aromatase is widely considered a prime medication example in this category.
First things first, let’s have a better grasp on what aromatase inhibitors accomplish before we look more closely at these medicines.
What is an Aromatase Inhibitor?
Aromatase inhibitors like Aromasin is a suicidal steroidal aromatase inhibitors with potent properties. This highlights the capacity of Aromasin to lower Estrogen levels by 85% in breast cancer patients, as demonstrated by studies. In suicide-inducing aromatase inhibitors, such as Aromasin, aromatase activity is permanently inhibited and disabled for good.
These medications won’t prevent the ovaries from producing Estrogen. They only reduce Estrogen levels in women whose ovaries do not make the hormone (like post-menopausal women).
The following AIs have been seen in studies to reduce the incidence of breast cancer:
- Exemestane (Aromasin)
- Anastrozole (Arimidex)
As with tamoxifen, these medications are more frequently used to manage hormone receptor-positive breast cancer than to reduce the chance of developing the disease.
Now take a closer look at this drug and other details like Arimidex vs. Aromasin.
What is Aromasin?
Aromasin is an aromatase inhibitor helping to:
- Lower the chance of hormone receptor-positive, early-stage breast cancer relapsing in post-menopausal ladies who had had tamoxifen for two to three years. The women shift to Aromasin and finish five years of hormonal therapy following surgery.
- Treat post-menopausal women whose breast cancer has progressed after treatment with tamoxifen.
Aromasin Basics
Pharmacia and Upjohn first made Exemestane to treat breast cancer in women who had gone through menopause. It is used as a second-line treatment for breast cancer when other first-line therapies, like Nolvadex, haven’t worked. Shortly after its creation, the Food and Drug Administration (FDA) approved using Aromasin (Exemestane) for retail, among other prescription drugs, in 1999.
The drug didn’t sell under the Aromasin brand name until 2000. Since it was first made available, its use and sales have spread worldwide, and it is now used in almost every country. There is just one legally made and sold Aromasin product at this time, and it is readily available worldwide under the brand name Aromasin. Aromasin (Exemestane) comes in tablets of 25mg, the standard dose. However, research shows that it works at doses as low as 2.5mg daily.
Aromasin For Bodybuilding
It is logical to assume that the qualities and effects of Aromasin bodybuilding would then be advantageous to the athlete who uses anabolic steroids for the goal of Estrogen control. It is used by sports people who take anabolic steroids to prevent Estrogen-related side effects such as gynecomastia, water retention and bloating, and an increased risk of cardiovascular disease (consequently, water retention rises from Estrogen).
This contradicts SERMs, such as Nolvadex, whose sole purpose is to prevent gynecomastia. Aromasin, like many other aromatase inhibitors, has been shown to increase the amount of natural testosterone made by men.
However, many people who use anabolic steroids and bodybuilders think that Aromasin is much more effective and useful than Arimidex.
Comparing Arimidex And Aromasin
Indeed, Arimidex is still much more prevalent among people who use anabolic steroids because Arimidex for men was created and launched before Aromasin, bodybuilders, and athletes who use anabolic steroids became aware of it earlier. Hence, they buy Arimidex more often.
In other words, Aromasin (Exemestane) was disregarded and neglected by many during its early days. However, numerous folks are beginning to recognize Aromasin’s superiority and advantages above the Arimidex Canada has to offer. Some of these benefits won’t appear in other aromatase inhibitors, particularly choosing credible Anastrozole Canada providers.
Recommended Dosage
There is no standard Aromasin dosage for cycle bodybuilding. Aromasin is officially authorized for the treatment of early and severe breast cancer. Aromasin contains the steroid-based active component exemestane. It functions by attaching to Aromatase, the enzyme responsible for converting testosterone (the primary sex hormone in men) into Estrogen (the primary sex hormone in women).
Aromasin and Anastrozole side effects have similar effects to testosterone replacement treatment by increasing testosterone levels in the body (TRT). Aromasin use for bodybuilding is considered an abuse of the medicine. In addition, the World Anti-Doping Agency prohibits Aromasin in all sports, including bodybuilding.
How does Aromasin Function?
Aromasin, like Anastrozole for men, works by inhibiting the enzyme aromatase, which converts small amounts of testosterone hormone into Estrogen. This indicates that less Estrogen is available to drive the proliferation of hormone-receptor-positive breast cancer cells, and Aromasin will not impact breast cancer without hormone receptors.
What to Expect While Taking Aromasin?
Aromatase inhibitors, like Aromasin and Anastrozole, are liked by athletes, bodybuilders, and other people who use anabolic steroids because they help reduce, prevent, or lessen the side effects of Estrogen. These side effects exist due to the aromatization (or conversion) of aromatizable androgens (like testosterone) into Estrogen, which often leads to much higher levels of Estrogen in the body than what usually is healthy.
Aromasin (Exemestane) is beneficial and very popular among people who use anabolic steroids because it stops Estrogen levels from rising at the source. It does this by binding to the aromatase enzyme and blocking it from working. This means that high levels of aromatizable androgens (like Dianabol, Testosterone, Boldenone, etc.) can’t turn into Estrogen, so there’s no threat of Estrogen-related adverse impacts.
Common Side Effects of Aromasin
Typical side effects of this drug, similar to anastrozole side effects include:
- Headache
- Joint pain
- Weight gain
- Nausea
- Hair loss
In rare cases, there could be severe adverse effects such as:
- Depression
- Allergic reaction
- High BP
- Bone loss
To avoid these, you should remember to stick to your Aromasin dosage, which generally doesn’t exceed 25 milligrams (mg) per day. In certain instances, your doctor may elevate your Aromasin dosage. In particular, if you take medicines that decrease the Aromasin or Arimidex dosage in your bloodstream, you might have to take 50 mg of Aromasin daily (or as recommended).
Conclusion
If you do have certain medical issues or other circumstances that affect your health, Aromasin might not be the best choice for you to use. Before beginning Aromasin bodybuilding, you must discuss your medical history with your treating physician, provided you want to achieve the best results.
References
https://pubmed.ncbi.nlm.nih.gov/10885600/
https://pubchem.ncbi.nlm.nih.gov/compound/Exemestane
https://www.wada-ama.org/sites/default/files/resources/files/2021list_en.pdf
http://labeling.pfizer.com/ShowLabeling.aspx?id=523§ion=PPI
https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020753s020lbl.pdf
https://pubmed.ncbi.nlm.nih.gov/30314452/
